Ischemia-reperfusion injury of the liver

Ischemia-reperfusion injury (IRI) of the liver is a major concern in clinical settings such as liver transplantation, hepatic resection, and trauma. IRI occurs when the blood supply to the liver is temporarily interrupted, leading to tissue damage and dysfunction. The subsequent restoration of blood flow, known as reperfusion, further exacerbates the injury, resulting in a cascade of inflammatory and oxidative stress responses. This article explores the mechanisms underlying IRI of the liver and discusses current strategies for minimizing its impact in clinical practice.